Education
PhD
in Biomedical Engineering Drexel University, Philadelphia 2008
MS in Biomedical Engineering Bogaziçi University, Istanbul 2003
BS in Mechanical Engineering Bogaziçi University, Istanbul 2001
Employment
Post-doctoral Researcher University College Dublin 2010-
Bionanosciences Lab, PI: Dr. Gil U. Lee
Post-doctoral Researcher CNRS-UPMC, Paris 2008-2009
Neurobiology of Adaptive Processes Lab, PI: Dr. Bernard Brugg
Research and Teaching Assistant Drexel University, Philadelphia 2004-2008
Cellular Mechanics Lab, PI: Dr. Kenneth A. Barbee
CAD/CAM Engineer Bogaziçi Yazılım A.S., Istanbul 2001-2003
Special Courses
Virtual Institute Summer Session by the Greater Philadelphia Bioinformatics Alliance 2006
Lectures and labs covered microarrays, genomics, proteomics, biostatistics and bio-molecular databases.
IEEE-EMBS/ASME Workshop on Nanoscale Modeling and Measurement of Mechanical Properties of Cell and Proteins 2006
Practical work consisted of thermal tuning of AFM and molecular simulation of protein interactions
8th Annual VCell Short Course by National Resource for Cell Analysis and Modeling 2007
MCell Workshop by National Resource for Biomedical Supercomputing 2007
Publications
MS Thesis: Shape Optimization of the Femoral Component of Cemented Hip Prosthesis Using Finite Element Analysis 2003
PhD Thesis: Mechanisms and Prevention of Axonal Damage in Response to Mechanical Trauma to Cultured Neurons 2008
Journal papers
Kilinc D, G Gallo and KA Barbee. 2008. Poloxamer 188 Blocks Mechanoporation-Induced Axonal Beading and Cytoskeletal Damage. Experimental Neurology, 212:422-430.
Kilinc D, G Gallo and KA Barbee. 2009. An Interactive Image Processing and Analysis Algorithm for the Quantification of Axonal Beading. Computer Methods and Programs in Biomedicine, 95:62-71.
Kilinc D, G Gallo and KA Barbee. 2009. Mechanical Membrane Injury Induces Axonal Beading through Localized Activation of Calpain. Experimental Neurology, 219:553-561.
Kilinc D,
JM Peyrin, V Soubeyre, S Magnifico, L Saias, JL Viovy and B Brugg. 2011. Wallerian-Like
Degeneration of Central Neurons after Synchronized and Geometrically Registered
Mass Axotomy in a Three-Compartmental Microfluidic Chip. Neurotoxicity Research, 19:149-161.
Conference papers
Kilinc D, G Gallo and KA Barbee. “Effects of Shear Stress Injury on the Morphology and Structure of Cultured Chick Forebrain Neurons (in Turkish),” BIYOMUT: Proceedings of the Biomedical Engineering National Meeting, pp. 191-196, May 25-26, 2005, Bogazici University, Istanbul, Turkey.
Kilinc D, G Gallo and KA Barbee, “Poloxamer 188 Reduces Axonal Beading Following Mechanical Trauma to Cultured Neurons,” EMBC07: Proceedings of the 29th IEEE EMBS Annual International Conference, pp. 5395-5398, Aug 23-26, 2007, Cité Internationale, Lyon, France.
Sasoglu FM, D Kilinc, K Allen and B Layton, “Towards a Method for Printing a Network of Chick Forebrain Neurons for Biosensor Applications,” EMBC07: Proceedings of the 29th IEEE EMBS Annual International Conference, pp. 4092-4095, Aug 23-26, 2007, Cité Internationale, Lyon, France.
Sasoglu FM, D Kilinc, K Allen and B Layton, “Parallel Force Measurements in Cell Arrays,” Proceedings of the ASME International Mechanical Engineering Congress and Exposition, November 11-15, 2007, Seattle, WA, USA.
Peyrin JM, L Saias, P Gougis, S Magnifico, S Betuing, D Kilinc, JL Viovy and B Brugg, “Microfluidic Chips with ‘Axon Diodes’ for Directed Axonal Outgrowth and Reconstruction of Complex Live Neural Networks,” MicroTAS 2008: Proceedings of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp. 1329-1331, Oct 12-16, 2008, San Diego, CA, USA
Platform presentations
Kilinc D, G Gallo and KA Barbee. “Morphological Response of Cultured Chick Forebrain Neurons to Mechanical Injury,” BMES Annual Fall Meeting, Oct 13-16, 2004, Philadelphia, PA, USA.
Kilinc D, G
Gallo and KA Barbee. “Effects of Shear Stress Injury on the Morphology and
Structure of Cultured Chick Forebrain Neurons (in Turkish),” BIYOMUT: Biomedical Engineering National Meeting, May
25-26, 2005, Bogazici University, Istanbul, Turkey.
Poster presentations
Kilinc D, G Gallo and KA Barbee. “Effects of Shear Stress Injury on the Morphology and Structure of Cultured Chick Forebrain Neurons,” BMES Annual Fall Meeting, Sep 28 - Oct 1, 2005, Baltimore, MD, USA.
Kilinc D, G Gallo and KA Barbee, “Shear Stress Injury Induces Morphological and Structural Changes in Cultured Chick Forebrain Neurons,” 24th Annual National Neurotrauma Symposium, July 7-9, 2006, St. Louis, MO, USA.
Barbee KA, D Kilinc, G Serbest, J Horwitz and G Gallo, “Cellular Mechanisms of Neural Injury and the Neuroprotective Effects of Poloxamer 188,” 5th World Congress of Biomechanics, July 29 - Aug 4, 2006, Munich, Germany.
Kilinc D, G Gallo and KA Barbee, “Poloxamer 188 Prevents Axonal Beading after Mechanical Trauma to Cultured Neurons by Maintaining Membrane Permeability,” 25th Annual National Neurotrauma Symposium, July 30 - Aug 1, 2007, Kansas City, MO, USA.
Kilinc D, G Gallo and KA Barbee, “Mechanically-induced Membrane Poration Causes Axonal Beading and Localized Cytoskeletal Damage via Calcium-dependent Calpain Activity,” 6th FENS Forum, July 12-16, 2008, Geneva, Switzerland.
Kilinc D, JM Peyrin, L Saias, JL Viovy and B Brugg, “Wallerian-Like Degeneration of Axotomized CNS Neurons in a Microfluidic Chip,” 4th Meeting on the Molecular Mechanisms in Neurodegeneration, May 8-10, 2009, Milano, Italy.
Kilinc D, JM Peyrin, L Saias, JL Viovy and B Brugg, “Wallerian-Like Degeneration of Axotomized CNS Neurons in a Microfluidic Chip,” ESF-EMBO Symposium: Biological Surfaces and Interfaces, June 27 - July 2, 2009, Sant Feliu de Guixols, Spain.
Magnifico S, JM Peyrin, D Kilinc, M Pietri, E Duplus, V Soubeyre, L Saias, JL Viovy and Brugg B, "Retrograde Propagation of Apoptotic Signals in CNS Neurons: Study in Microfluidic Culture Chambers," The 9th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD), Mar 11-15, 2009, Prague, Czech Republic.
Kilinc D, JM Peyrin, L Saias, JL Viovy and B Brugg, “Wallerian-Like Degeneration of Axotomized CNS Neurons in a Microfluidic Chip,” The 9th International Congress on Cell and Tissue Polarity, Nov 16-17, 2009, Paris, France.
Magnifico S, L Saias, E Duplus, D Kilinc, MC Miquel, JL Viovy, B Brugg and JM Peyrin, “Dying Back Pattern of Central Nervous System Neurons Involves Local Caspase Activation,” 7th FENS Forum, July 03-07, 2010, Amsterdam, The Netherlands.
Kilinc D, E Duplus, Y Von Boxberg, L Saias, JL Viovy, JM Peyrin and B Brugg, “Axonal Protein Chemistry Using Microfluidic Devices,” 7th FENS Forum, July 03-07, 2010, Amsterdam, The Netherlands.
Kilinc D, E Duplus, JM Peyrin, B Brugg, G Gallo and KA Barbee, “Axonal Cytoskeletal Changes Following Mechanical Injury,” ESF-EMBO Symposium: Emergent Properties of the Cytoskeleton: Molecules to Cells, Oct 3-8, 2010, Sant Feliu de Guixols, Spain.
Magnifico S, L Saias, E Duplus, D Kilinc, MC Miquel, JL Viovy, JM Peyrin and B Brugg, “Exposure of Neurons to ß-Amyloid Peptides Induces an Axonal Dying Back Pattern,” Society for Neuroscience 40th Annual Meeting, Nov 10-13, 2010, San Diego, CA, USA.
Honors and Awards
Ranked in top 10 in the nation-wide secondary education entrance exam, Turkey, 1988.
Ranked in top 100 in the nation-wide university entrance exam, Turkey, 1996.
Ranked in top 100 in the nation-wide post-graduate education entrance exam, Turkey, 2001.
Critical Research Fellow, Drexel University Synergy Grant GRID awards, 2005.
Student travel grant for National Neurotrauma Society Annual Meeting, St. Louis, MO, USA, 2006.
Research Fellow, Drexel University Neuroengineering Major Research Initiative, 2007-2008.
Travel grant for ESF-EMBO Symposium on Biological Surfaces and Interfaces, Sant Feliu de Guixols, Spain, 2009.
Fabrication grant (with Prof. Gil Lee) from the Tyndall National Institute for "NeuroCHIP" project, 2010.
Marie Curie Intra-European Fellowship, 2011-2013.
Professional Memberships
New York Academy of Science (since 2005)
IEEE Engineering in Medicine and Biology (2005-2007)
National Neurotrauma Society (2006-2008)
Turkish American Scientists and Scholars Association (2006-2008)
Neuroscience Society of Turkey (since 2008)
Leadership Positions
Altinyurt Sports Club, Istanbul: Fencing team captain (1993-1998), board member (2001)
Bogazici University Underwater Sports Club, Istanbul: Board member, scuba instructor (1999-2003)
Derin Diving Magazin, Istanbul: Co-editor, writer (2000-current)
